Bioactive, Human CXCR4 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24005 |
| Expression Host | HEK293T |
| Verified Applications | ELISA for CXCR4-specific antibody binding assays. |
| Suggested Applications | Animal immunization, RUO. |
| Amino Acid Range | Met1-Ser352 |
For Research Use Only
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Anti-human CXCR4 Antibody Binding
Immobilized human CXCR4 VLP (Cat. No. CMP-24005) at 5 μg/mL (100 μL/well) can bind anti-human CXCR4 monoclonal antibody with EC50 range of 2.3-9.19 ng/mL (QC tested).
Human CXCR4 Full Length,
DLS
The mean peak diameter (nm) of the full length CXCR4 displayed on nanoparticles is 185.3 with a range of 161.3-203.5 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human CXCR4
UniProt #: P61073
Protein Construct: The human CXCR4 full length protein (amino acids Met1-Ser352) is displayed on nanoparticles and expressed in HEK293T cells.
Formulation: 0.2μm filtered PBS, pH 7.4, no preservatives
Shipping: Frozen Dry Ice
Storage: -80°C
Human CXCR4 (C-X-C motif chemokine receptor 4) is a receptor for chemokine CXCL12 and co-receptor for HIV-1 envelope glycoprotein (Env), also known as FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, WHIMS1, and D2S201E. CXCR4 (CMP-24005) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR4 full length protein (amino acids Met1-Ser352; UniProt# P61073), displayed on nanoparticles (CMP-24005) mimics the native protein conformation on the cell surface. The CXCR4 nanoparticle (CXCR4 CMP) is expressed in HEK293 cells. The CXCR4 CMP has potent binding to its ligands CXCL12 and HIV-1 Env, and the CXCR4-specific antibodies.
Background
C-X-C chemokine receptor type 4 (CXCR4) is also known as CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 12 (CXCL12), also known as stromal cell-derived factor 1 (SDF-1). CXCR4 also acts as a co-receptor for HIV infection.
Alternate Names: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, WHIMS1, and D2S201E