Bioactive, Human Claudin 9 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24009 |
| Expression Host | HEK293T |
| Verified Applications | ELISA and Western blot for Claudin 9 specific antibody binding assays. |
| Suggested Applications | BLI, SPR and animal immunization, RUO. |
| Amino Acid Range | Met1 - Val217 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 9 VLP (Cat. No. CMP-24009) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 9 antibody with half maximal effective concentration (EC50) range of 18.6 to 74.4 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 183 with a range of 165.6-202.4 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human Claudin-9
UniProt #: O95484
Protein Construct: Claudin 9 protein contains 217 amino acids (Met1 – Val217; UniProt# O95484), and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 9, also known as Claudin-9 and CLDN9, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, one intracellular loop, and both N-terminus and C-terminus ends towards the cytosol. Human Claudin 9 is a member of the Claudin protein family, involved with tight junctions and cell-to-cell adhesion. Claudin 9 is expressed at low levels in normal tissue, but is ectopically expressed in numerous cancers. Claudin 9 is a novel prognostic biomarker for endometrial cancer and also functions as a co-receptor for Hepatitis C Virus.
Alternate Names: Claudin-9, CLDN9