Bioactive, Human Claudin 9 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24009 |
| Expression Host | HEK293T |
| Verified Applications | ELISA and Western blot for Claudin 9 specific antibody binding assays. |
| Suggested Applications | BLI, SPR and animal immunization, RUO. |
| Amino Acid Range | Met1 - Val217 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 9 VLP (Cat. No. CMP-24009) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 9 antibody with half maximal effective concentration (EC50) range of 18.6 to 74.4 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 183 with a range of 165.6-202.4 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human Claudin-9
UniProt #: O95484
Protein Construct: Claudin 9 protein contains 217 amino acids (Met1 – Val217; UniProt# O95484), and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 9, also known as Claudin-9 and CLDN9, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, one intracellular loop, and both N-terminus and C-terminus ends towards the cytosol. Human Claudin 9 is a member of the Claudin protein family, involved with tight junctions and cell-to-cell adhesion. Claudin 9 is expressed at low levels in normal tissue, but is ectopically expressed in numerous cancers. Claudin 9 is a novel prognostic biomarker for endometrial cancer and also functions as a co-receptor for Hepatitis C Virus.
Alternate Names: Claudin-9, CLDN9
Learn more about Claudin 9
Leveraging Nature’s Blueprints for Breakthrough Bioactive Claudin Integral Membrane Proteins
Nature holds the blueprint for many of science’s most promising therapeutic solutions. At Conigen, we’ve harnessed these native designs to introduce our latest Claudin protein