Bioactive, Human Claudin 6 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24007 |
| Expression Host | HEK293T |
| Verified Applications | ELISA for Claudin-6 specific antibody binding assays; animal immunization, RUO |
| Amino Acid Range | Met1 - Val 220 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 6 VLP (Cat. No. CMP-24007) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 6 antibody with half maximal effective concentration (EC50) range of 6.6 – 26.3 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 177.6 with a range of 162.9-196.6 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human Claudin-6
UniProt #: P56747
Protein Construct: Claudin 6 contains 220 amino acids (Met1 – Val 220; UniProt# P56747), and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 6, also known as CLDN6, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 6 is a member of Claudin protein family and involved in tight junction and cell-to-cell adhesion. It is highly and widely expressed on various tumor cells, and play critical role in cancer initiation and progression, and a promising target for cancer therapeutics.
Alternate Names: Claudin-6, CLDN6
Learn more about Claudin 6
Leveraging Nature’s Blueprints for Breakthrough Bioactive Claudin Integral Membrane Proteins
Nature holds the blueprint for many of science’s most promising therapeutic solutions. At Conigen, we’ve harnessed these native designs to introduce our latest Claudin protein