Bioactive, Human Claudin 18.2 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24001 |
| Expression Host | HEK293T |
| Verified Applications | ELISA and Western blot for Claudin 18.2-specific antibody binding assays. |
| Suggested Applications | ELISA for Claudin 18.2-specific antibody binding assays; animal immunization, RUO |
| Amino Acid Range | Met1-Val261 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 18.2 VLP (Cat. No. CMP-24001) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 18.2 antibody with half maximal effective concentration (EC50) range of 19.4-77.6 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 194.4 with a range of 184.4-204.4 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human Claudin 18.2
UniProt #: P56856-2
Protein Construct: Claudin 18.2 full length protein (amino acids Met1-Val261; UniProt# P56856-2) , displayed on nanoparticles mimics the native protein conformation on the cell surface.
Background
Claudin 18.2, also known as CLDN18.2, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 18 is a member of Claudin protein family and involved in tight junction and cell-to-cell adhesion. Claudin 18.2 is not expressed in any healthy tissues with the exception of gastric mucosa. It is highly and widely expressed on various tumor cells including gastric cancer and pancreatic cancer. Claudin 18.2 plays critical role in cancer initiation and progression, and is a promising target for cancer therapeutics.
Alternate Names: SFTA5, and SFTPJ