Bioactive, Human Claudin 4 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24006 |
| Expression Host | HEK293T |
| Verified Applications | ELISA and Western blot for Claudin 4-specific antibody binding assays. |
| Suggested Applications | ELISA for Claudin 4-specific antibody binding assays; animal immunization, RUO. |
| Amino Acid Range | Met1 - Val209 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 4 VLP (Cat. No. CMP-24006) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 4 antibody with half maximal effective concentration (EC50) range of 48.6-194.4 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 199.2 with a range of 189.2-209.2 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Claudin 4
UniProt #: NP_001296.1
Protein Construct: Claudin 4 protein contains 209 amino acids (Met1 – Val209; UniProt# NP_001296.1), and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 4, also known as CLDN4, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma. As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.
Alternate Names: Claudin-4, CLDN4
Learn more about Claudin
Leveraging Nature’s Blueprints for Breakthrough Bioactive Claudin Integral Membrane Proteins
Nature holds the blueprint for many of science’s most promising therapeutic solutions. At Conigen, we’ve harnessed these native designs to introduce our latest Claudin protein