Bioactive, Human Claudin 6 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24007 |
| Expression Host | HEK293T |
| Verified Applications | ELISA for Claudin-6 specific antibody binding assays; animal immunization, RUO |
| Amino Acid Range | Met1 - Val 220 |
For Research Use Only
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Bioactivity – Antibody Binding
Immobilized human Claudin 6 VLP (Cat. No. CMP-24007) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human Claudin 6 antibody with half maximal effective concentration (EC50) range of 6.6 – 26.3 ng/mL (QC tested).
Dynamic Light Scattering
The mean peak diameter (nm) of the CMP is 177.6 with a range of 162.9-196.6 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human Claudin-6
UniProt #: P56747
Protein Construct: Claudin 6 contains 220 amino acids (Met1 – Val 220; UniProt# P56747), and is displayed on nanoparticles that mimics the native protein conformation on the cell surface.
Background
Claudin 6, also known as CLDN6, is an integral membrane protein with 4 transmembrane domains, two extracellular loops, two intracellular loops, both N-terminus and C-terminus ends towards the cytosol. Human Claudin 6 is a member of Claudin protein family and involved in tight junction and cell-to-cell adhesion. It is highly and widely expressed on various tumor cells, and play critical role in cancer initiation and progression, and a promising target for cancer therapeutics.
Alternate Names: Claudin-6, CLDN6