Bioactive, Human CXCR5 Full Length Protein, Displayed on Nanoparticles
| Product Code | CMP-24014 |
| Expression Host | HEK293T |
| Verified Applications | ELISA for CXCR5-specific antibody binding assays. |
| Suggested Applications | Animal immunization, RUO. |
| Amino Acid Range | Met1- Phe372 |
For Research Use Only
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Anti-human CXCR5 Antibody Binding
Immobilized human CXCR5 VLP (Cat. No. CMP-24014) at 5 μg/mL (100 μL/well) can bind monoclonal anti-human CXCR5 antibody with EC50 range of 6.4-25.7 ng/mL (QC tested).
Human CXCR5 Full Length,
DLS
The mean peak diameter (nm) of the full length CXCR5 nanoparticles is 187.6 with a range of 170.9-207.8 with more than 95% intensity as determined by dynamic light scattering (DLS).
Specifications
Protein Name: Human CXCR5
UniProt #: P32302
Protein Construct: The human CXCR5 full length protein is displayed on nanoparticles and mimics the native protein conformation on the cell surface.
Formulation: 0.2μm filtered PBS, pH 7.4, no preservatives
Shipping: Frozen Dry Ice
Storage: -80°C
Human CXCR5 (C-X-C motif chemokine receptor 5) is a receptor for chemokine CXCL13, also known as BLR1, CD185, and MDR15. CXCR5 (CMP-24014) is a G protein-coupled receptor (GPCR) with seven transmembrane domains. The human CXCR5 full length protein (amino acids Met1-Phe372; UniProt# P32302), displayed on nanoparticles (CMP-24001) mimics the native protein conformation on the cell surface. The CXCR5 nanoparticle (CXCR5 CMP) is expressed in HEK293 cells. The CXCR5 CMP has potent binding to its ligand CXCL13 and the CXCR5-specific antibodies.
Background
C-X-C chemokine receptor type 5 (CXCR5) is also known as CD185, Burkitt lymphoma receptor 1 (BLR1) and monocyte-derived receptor 15 (MDR15). CXCR-5 is a G protein-coupled receptor (GPCR) for the C-X-C motif chemokine 13 (CXCL13). It enables T cells to migrate to lymph node and the B cell zones.
Alternate Names: BLR1, CD185, and MDR15