Conigen Soluble Dimeric Recombinant Proteins
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These bioactive homodimer and heterodimer proteins are designed to mimic native protein complexes with the ectodomain of a Type I transmembrane protein genetically fused to a proprietary cis-dimer motif with a stabilization element at the C-terminus to promote soluble dimer formation.
Applications include:
Tool-molecules – immunogen / antigen, antibody generation, screening, characterization, protein engineering
Alternative to live cell systems
Receptor-ligand interactions – ELISA, flow cytometry, SPR, BLI, and other binding potency methods
Drug screening and bioactivity evaluation with greater sensitivity and wider screening window
Agonist: drug binding ability to receptor
Antagonist: drug blocking receptor/ligand binding
Structural analyses
Examples: CD4 homodimer and INFa R1/R2 heterodimer
Conigen Membrane Protein Nanoparticles
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These bioactive full-length target membrane proteins are optimized to enhance surface expression on VLPs. The viral capsid backbone is engineered to increase VLP release for higher production yield.
Applications include:
Examples: Claudin 18.2 and CXCR4
Scalable Standardized Procedures to Ensure Consistent Product Quality
From difficult to expression proteins to immunogenicity challenges, our team supports custom projects for protein and antibody generation with a modular, data-backed workflow.
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